In vitro cytotoxicity of GO–DOx on FaDu squamous carcinoma cell lines
نویسندگان
چکیده
We have synthesized graphene oxide (GO) nanosheets using modified Hummer's method and conjugated it with doxorubicin (DOx), an anticancer drug. Drug release kinetics from GO-DOx conjugate indicated the drug release at acidic pH. MTT assay performed on FaDu hypopharyngeal cancer cell lines revealed that the GO-DOx nanoconjugate inhibited cell proliferation more efficiently compared with pure DOx. Preliminary results indicate the potential of designed GO-DOx drug conjugate for head and neck cancer.
منابع مشابه
Cytotoxic activity of in vitro cultures of Linum spp.
There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...
متن کاملCytotoxic activity of in vitro cultures of Linum spp.
There are some reports on the lignan constituents of Linum spp. In this study, we investigated the cyototoxicity of Linum spp. in vitro cultures for the first time. If they show significant cytotoxic activity, they will be valuable candidates for isolation of cytotoxic compounds in large scale from them by tissue culture technology. In our study, we chose normal root, hairy root and calli cultu...
متن کاملبررسی اثرپکتین تغییر یافته مرکبات (MCP) و دوکسوروبیسین برقدرت زیستایی، مورفولوژی و چرخه سلولی دردو دودمان سلولی سرطان پروستات انسانی، DU-145 وLNCaP
Background and Objective: This study was conducted to evaluate the effect of PectaSol on modification of Doxorubicin (Dox) cytotoxicity and apoptosis and cell cycle in prostate cancer cell lines (DU-145 & LNCaP) Materials and Methods: Human prostate carcinoma DU-145 and LNCaP cell lines were treated with various concentrations of pectaSol,...
متن کاملCircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance
Objective(s): Circular RNAs (circRNAs), a new class of non-coding RNAs, have emerged as important regulators during tumorigenesis. However, the functions of circRNAs have not been completely clarified in the progression of cancers. In our study, a novel circRNA hsa_circ_0109291 was investigated in oral squamous cell carcinoma (OSCC) tissues and cell lines. Materials and Methods: The expression ...
متن کاملAn In vitro Study on Curcumin Delivery by Nano-Micelles for Esophageal Squamous Cell Carcinoma (KYSE-30)
Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. C...
متن کامل